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xCELLigence Real-Time Cell Analyzer
The xCELLigence® RTCA instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner. The instrument is placed in a standard CO2 cell culture incubator and interfaces via a cable with analysis and control units that are housed outside the incubator. User friendly software allows for real-time control and monitoring of the instrument, and includes real-time data display and analysis functions.
By skipping the guesswork associated with end-point assays and eliminating the time- and labor-intensive steps of traditional cell-based assays, real-time cell analysis (RTCA) with the xCELLigence® RTCA vastly improves efficiency and overall productivity. By eliminating the need for labels/dyes, the physiological relevance of acquired data is maximized.
Non-Invasive and Label-Free Monitoring of Cells
The xCELLigence Real-Time Cell Analysis (RTCA) instruments utilize patented microtiter plates (E-Plates®) which contain gold biosensors embedded in the bottom of each well. These biosensors continuously and non-invasively monitor changes in cell number, cell size, cell barrier function, and cell-substrate attachment quality.
Within E-Plate wells adherent cells act as insulators, restricting the flow of a miniscule electric current between the biosensors. This signal is measured automatically, at a frequency defined by the user (every 10 seconds, once per hour, etc.), and provides a dynamic view of cell health and behavior at an unprecedented level of detail.
Compatible with a Wide Range of Cell-Based Assays
Because dynamic changes in cell number, cell size, cell barrier function, and cell-substrate attachment quality are influenced by a large number of biochemical pathways, xCELLigence can be used for dozens of different applications. These include, but are not limited to:
- Immune cell killing
- Cell invasion and migration
- Cardiotoxicity testing
- Drug discovery/development
- Receptor signaling
- Virus cytopathic effects
- Biofilm dynamics
- Cell-cell interactions
xCELLigence Real-Time Cell Analyzer
The xCELLigence® RTCA instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner. The instrument is placed in a standard CO2 cell culture incubator and interfaces via a cable with analysis and control units that are housed outside the incubator. User friendly software allows for real-time control and monitoring of the instrument, and includes real-time data display and analysis functions.
By skipping the guesswork associated with end-point assays and eliminating the time- and labor-intensive steps of traditional cell-based assays, real-time cell analysis (RTCA) with the xCELLigence® RTCA vastly improves efficiency and overall productivity. By eliminating the need for labels/dyes, the physiological relevance of acquired data is maximized.
Non-Invasive and Label-Free Monitoring of Cells
The xCELLigence Real-Time Cell Analysis (RTCA) instruments utilize patented microtiter plates (E-Plates®) which contain gold biosensors embedded in the bottom of each well. These biosensors continuously and non-invasively monitor changes in cell number, cell size, cell barrier function, and cell-substrate attachment quality.
Within E-Plate wells adherent cells act as insulators, restricting the flow of a miniscule electric current between the biosensors. This signal is measured automatically, at a frequency defined by the user (every 10 seconds, once per hour, etc.), and provides a dynamic view of cell health and behavior at an unprecedented level of detail.
Compatible with a Wide Range of Cell-Based Assays
Because dynamic changes in cell number, cell size, cell barrier function, and cell-substrate attachment quality are influenced by a large number of biochemical pathways, xCELLigence can be used for dozens of different applications. These include, but are not limited to:
- Immune cell killing
- Cell invasion and migration
- Cardiotoxicity testing
- Drug discovery/development
- Receptor signaling
- Virus cytopathic effects
- Biofilm dynamics
- Cell-cell interactions
xCELLigence® Immunotherapy Kits:
Monitor the Efficacy of Liquid Cancer Immunotherapies inside your incubator
Use xCELLigence Immunotherapy Kits with your real-time cell analysis (RTCA®) system for a non-invasive solution to a broad range of liquid cancer immunotherapies and suspension tumor cell killing applications.
- Label-Free: Allowing for more physiological assay conditions; labeling or secondary assays aren’t required
- Real-Time: Quantitative monitoring of both fast (hours) and slow (days) killing kinetics
- Sensitive: Capable of evaluating low effector cell to target cell ratios that are physiologically relevant
- Simple Workflow: Requires only the addition of effector cells to target cells (in the presence or absence of antibodies); homogeneous assay without additional sample handling
- Automatic Data Plotting: RTCA software Pro enables facile data display and objective analysis, precluding the subjective data vetting that is common to imaging-based assays
